Synergistic Sustained Drug-Release System Based on Immobilized Rhamnus frangula L. Phytoextract into Layered Double Hydroxide Covered by Biocompatible Hydrogel

This work focuses on the synergetic effect obtained by immobilization of Rhamnus frangula L. (RfL) phytoextract in layered double hydroxides (LDHs) matrixes and their subsequent encapsulation into biocompatible hydrogels (HG). In this respect, LDHs were used as hosts for a reconstruction method, after which LDHsRfL embedded hydrogel (HG) matrixes, based polyethylene glycol diacrylate (PEGDA), radical polymerization reaction. The resulted composites characterized modern methods, while swelling rheology measurements revealed that HG steadily improved content RfL immobilized (LDHsRfL) increased. following vitro sustained release was highlighted at pH 6.8, case composite HGs with presented an behavior over LDHsRfL, thus, underlining synergistic PEGDA network LDH particles slow-release behavior. kinetic models from clearly indicate is diffusion controlled all cases. final described here may find applications pharmaceutical field devices drugs.